The large intestine does far more than absorb water and store waste—it plays a vital role in maintaining gut health, hosting the microbiome, and influencing immunity and overall wellbeing. Yet, conditions affecting the colon are among the most frequent reasons for outpatient visits, ranging from functional bowel disorders to inflammatory and neoplastic diseases.

In Episode 4 of Mysteries of the Gut, experts take you on a fascinating journey through the astonishing world of the large intestine. The discussion will explore its structure and function, common clinical disorders, and practical approaches to evaluating symptoms such as altered bowel habits, lower GI bleeding, and chronic constipation or diarrhea. Combining clinical relevance with engaging insights, this episode will help clinicians better understand the colon and translate that knowledge into everyday patient care.

Mysteries of The Gut: Episode 4 - Astonishing world of Large intestine

The small intestine is the body's primary site of digestion and nutrient absorption, yet its disorders often present with vague, overlapping symptoms that can make diagnosis challenging. From malabsorption syndromes and inflammatory conditions to infections and functional disorders, understanding the small intestine is key to solving many everyday gastroenterology puzzles.

In Episode 3 of Mysteries of the Gut, the spotlight turns to the remarkable world of the small intestine. Through an engaging, expert-led discussion, the session will unravel its unique physiology, common clinical conditions, and practical approaches to evaluation and management. Blending foundational concepts with real-world clinical insights, this episode promises to help clinicians navigate small bowel disorders with greater confidence and clarity.

Mysteries of The Gut: Episode 3 -  Amazing world of Small intestine

The stomach is far more than a reservoir for food—it is a dynamic organ that orchestrates digestion, regulates appetite, and serves as a critical barrier against pathogens. Yet many aspects of its function remain underappreciated in everyday clinical practice.

In this episode of Mysteries of the Gut: GUT Revisited, Dr. Mahadev Desai and Dr. Manish Bhatnagar explore the fascinating physiology of the stomach, from acid secretion and gastric motility to the mechanisms underlying common gastric disorders. Through engaging discussion and clinical correlations, the session will uncover how this remarkable organ influences both gastrointestinal and systemic health.

Mysteries of The Gut: Episode 2 – Mysteries of the Stomach

Mysteries of the Gut: GUT Revisited is a 5-part conversational clinical series on Medflix that explores the science of the gut—from core physiology to the microbiome and the gut–brain axis. Led by Dr. Mahadev Desai, with expert insights from Dr. Manish Bhatnagar, the series bridges the gap between foundational concepts and everyday clinical decision-making.

Inspired by Giulia Enders’ Gut, each session translates complex biological ideas into practical, case-linked insights relevant for clinicians. With a live pre-session quiz and interactive discussions, the series is designed to make learning engaging, applied, and clinically meaningful.

Quiz is now LIVE!

Test your clinical instincts, compete with fellow doctors, and stand a chance to win the bestselling book Gut by Giulia Enders.

▶️ [Play Quiz](https://pxmd.co/mogplay)

Mysteries of the Gut: Episode 1 - Oral Cavity, Pharynx and Esophagus

Gastrointestinal complaints in the elderly often present differently, with overlapping symptoms, multiple comorbidities, and age-related physiological changes complicating diagnosis and management. This session unpacks how aging impacts gut function and alters the presentation of common GI disorders.

Dr Manish Bhatnagar will guide clinicians through a practical, case-based approach to evaluating GI symptoms in older adults: highlighting red flags, common diagnostic pitfalls, and rational investigation strategies. The focus will be on differentiating benign age-related changes from pathology, optimizing treatment choices, and improving outcomes in this vulnerable population.

Decoding the Aging Gut: Elderly with GI Symptoms

Obesity has evolved into a global health crisis, affecting individuals across all age groups and socioeconomic backgrounds. Often underestimated, its widespread impact extends beyond weight, contributing to a growing burden of non-communicable diseases and straining healthcare systems worldwide. In this session titled "Globesity: The Global Pandemic of Obesity - The Good, The Bad, The Ugly," Dr. Manish Bhatnagar will unpack the complex layers of this modern epidemic. From emerging insights into metabolic health to the societal and clinical challenges in addressing obesity, the session offers a comprehensive look at what we know, what we’re getting wrong, and what must change going forward.

Globesity: The Global Pandemic of Obesity - The Good, The Bad, The Ugly

Ultra-processed foods have become dietary staples—but at what cost? In this eye-opening session, Dr. Manish Bhatnagar, senior gastroenterologist, explores the growing impact of ultra-processed foods on gut health, metabolic disease, and chronic inflammation. Backed by clinical evidence and patient cases, this session will help clinicians recognize the subtle and not-so-subtle manifestations of poor dietary habits and offer practical guidance for counseling patients. Don’t miss this opportunity to connect the dots between the modern diet and real-world GI disorders.

The Ultra-Processed Food Menace

Join us for the Final Presentation on Ulcerative Colitis and Atopic Dermatitis, the grand finale of the PRISM Research Program. Six outstanding participants will present their cutting-edge research to a distinguished panel of four jury members. This session promises to be a celebration of scientific excellence, highlighting innovative work on two critical health topics.

  

Agenda

  

Ulcerative Colitis Presentations:

-   Aiswarya Raju – Navigating through the dietary triggers of Ulcerative Colitis
    

  

-   Dr. Harmanjeet Dhillon – Correlate clinical severity, endoscopic findings, histology scoring and inflammatory markers in patients of Ulcerative Colitis
    

  

-   Dr. Sushil Kumar – Psychological Impact of Ulcerative Colitis: A Prospective Study on Anxiety and Depression in Newly Diagnosed Patients
    

  

-   Dr. Tanvi Reddy – Psychosocial impact of Ulcerative Colitis – A qualitative study
    

  


Atopic Dermatitis Presentations:

-   Dr. Aswini – Comprehensive review and comparison of scales for assessing Atopic Dermatitis
    

  

-   Dr. Kannan – Association between duration of breastfeeding and severity of Atopic Dermatitis in children aged 1 to 12 years: A cross-sectional study
    

  

Don’t miss this opportunity to gain insights into emerging trends in medical research and support these brilliant researchers as they compete for top honors.

Prism Final Presentation: Ulcerative Colitis & Atopic Dermatitis

Gallbladder disorders can present with a wide range of symptoms, from mild discomfort to acute abdominal emergencies, making timely diagnosis and management crucial. In this session, Dr. Manish Bhatnagar, a leading expert in gastroenterology, will explore the clinical nuances of gallbladder disorders, including gallstones, acute and chronic cholecystitis, and biliary colic. Through case-based discussions and real-world insights, Dr. Bhatnagar will shed light on diagnostic challenges, treatment options, and strategies to prevent complications. This session aims to equip clinicians with practical knowledge to improve patient outcomes. Don’t miss this deep dive into gallbladder health!

Gall Bladder Disorders

In this informative session, Dr. Manish Bhatnagar will delve into the critical aspects of managing GI infections and the responsible use of antibiotics. Learn how to diagnose and treat GI infections effectively, minimize antibiotic misuse, and implement best practices in patient care. This session is a must-attend for all healthcare professionals seeking to enhance their knowledge and skills in managing GI infections.

GI Infections and Misuse of Common Antibiotics

In this comprehensive session, our expert, Dr. Manish Bhatnagar, will provide an in-depth update on the latest advances in the diagnosis, treatment, and management of H. Pylori infections. Learn about the recent guidelines, antibiotic resistance patterns, and novel therapeutic approaches. This session is a must-attend for healthcare professionals seeking to enhance their knowledge and skills in managing H. Pylori-related disorders.

Update on H Pylori

Despite the availability of effective screening and treatment options, the management of patients with incidentally detected HBsAg positivity is often complex, requiring careful consideration of liver function, viral load, and potential risk factors for progression to chronic disease or liver-related complications. This session will delve into the appropriate clinical approach for managing patients with incidentally detected HBsAg positive status. Dr. Manish Bhatnagar, will discuss the latest diagnostic strategies, risk assessment tools, and treatment options, as well as the importance of patient education and follow-up care. Attendees will gain practical insights into how to navigate the often-overlooked aspects of managing this condition in routine clinical practice.

Approach to Patient with Incidentally Detected HBsAG Positive Status

Constipation is a prevalent yet often overlooked gastrointestinal complication in patients with Type 2 Diabetes Mellitus (T2DM). Affecting up to 60% of diabetic patients, this condition significantly impacts quality of life and may lead to severe complications if left untreated. Despite its prevalence, the connection between diabetes and constipation remains understudied and frequently undertreated in clinical practice. This session will explore the multifaceted relationship between T2DM and constipation, including the role of medications, and lifestyle factors. Join us as Gastroenterologist Dr. Manish Bhatnagar discuss the pathophysiology, diagnosis, and management strategies for this important complication. 

Diabetes and Constipation: An Overlooked, Understudied and Undertreated GI Complication in T2DM Patients 

Ascites is the pathologic accumulation of fluid within the peritoneal cavity. It is the most common complication of cirrhosis and occurs in about 50% of patients with decompensated cirrhosis in 10 years. Other causes of Ascites include malignant neoplasia, tuberculous infection, cardiac insufficiency, renal diseases, etc. Effective management of ascites is crucial for improving patient outcomes and quality of life. Join us as Gastroenterologist Dr. Manish Bhatnagar discusses these key aspects of ascites management, bringing their expertise in diagnosing and treating this challenging condition. Enhance your clinical skills and stay updated on the latest best practices to improve patient care and outcomes.

Management of Ascites

Nonalcoholic fatty liver disease (NAFLD) is a condition in which fat builds up in your liver. Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are types of NAFLD. NAFLD is a spectrum of diseases including simple fatty liver, NASH, fibrosis, and cirrhosis, with a complex ‘multi-hit’ pathophysiology. Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of about 25%. Incidence is increasing with rising levels of obesity, type 2 diabetes, and metabolic syndrome, and NAFLD is predicted to become the leading cause of cirrhosis requiring liver transplantation in the next decade. Diagnosis involves the identification of hepatic steatosis, followed by risk stratification for significant fibrosis. Renowned gastroenterologist Dr. Manish Bhatnagar will share his insights on this pressing health issue.

Non-alcoholic Fatty Liver Disease

The Hepatitis A virus is a common infectious etiology of acute hepatitis worldwide and is most commonly transmitted through the oral-fecal route via exposure to contaminated food, water, or close physical contact with an infectious person. Hepatitis E virus causes about 20 million new infections and over 55,000 deaths annually. It commonly causes an acute illness that is typically indistinguishable from other forms of acute hepatitis. A vast majority of patients are asymptomatic or have a mild clinical disease. Drug-induced liver injury (DILI) is an acute or chronic response to a natural or manufactured compound, where treatment begins with the removal of the offending agent, and the prognosis for recovery is usually favourable after discontinuation of the drug. Join renowned Gastroenterologist, Dr. Manish Bhatnagar as he shares his expertise on Hepatitis A, E and DILI.

Physician's Guide to Hepatitis : Decoding Hepatitis A, E and Drug - Induced Liver Injury

Hepatitis B virus and Hepatitis C virus infections are major causes of acute and chronic liver disease (e.g. cirrhosis and hepatocellular carcinoma) globally and cause an estimated 1.4 million deaths annually. While HCV is the most prevalent cause of parenteral hepatitis worldwide, around one-third of the global population has had an infection with the Hepatitis B virus. Testing and diagnosis of hepatitis B and C infection is the gateway for access to both prevention and treatment services and is a crucial component of an effective response to the hepatitis epidemic. In this session, Medflix Superstar, Dr. Manish Bhatnagar will take us through the Basic Guide to Hepatitis B and Hepatitis C.

Physician's Guide to Hepatitis : Hepatitis B & C

In clinical practice, it is normal to face challenging clinical cases, whose diagnosis does not seem obvious. While classical presentations of uncomplicated disease are diagnosed by pattern recognition, complex problems require analytical thought in addition. In this setting, the physician will need to make use of the complementary laboratory and imaging tools. Nevertheless, the clinical history is the most fundamental tool that triggers the diagnostic process followed by a detailed, careful, and precise physical examination. In this session, Medflix superstar, Dr. Manish Bhatnagar will address the Diagnoses that may be missed and share tips to approach medical conditions like Lactose Intolerance, Eosinophilic esophagitis, and Celiac disease.

Diagnoses Flying Under the Physician's Radar: From Lactose Intolerance to Celiac Disease

Chronic diarrhoea, defined as a decrease in stool consistency for more than four weeks, is a common but challenging clinical scenario. It can be divided into three basic categories: watery, fatty (malabsorption), and inflammatory. However, some of these categories tend to overlap. Nevertheless, it is absolutely important to take an effective history and to perform a careful physical examination. In this session, Dr. Manish Bhatnagar, a renowned Gastroenterologist and a Medflix Superstar will take us through the list of diagnostic possibilities in these patients using a case-based approach.

Chronic Diarrhoea : Think Beyond the Gut

Chronic pancreatitis is a progressive inflammatory disorder that results in irreversible destruction of exocrine and endocrine pancreatic parenchyma caused by atrophy and/ or replacement with fibrotic tissue. Functional consequences include severe abdominal pain, diabetes mellitus, and malabsorption. When pancreatic enzyme activity in the intestinal lumen is reduced below the threshold needed for digestive functions, primarily pancreatic lipase, it is referred to as pancreatic exocrine insufficiency (PEI). Top Gastroenterologist, Dr. Manish Bhatnagar will take us through the etiology, pathophysiology, evaluation, and management of chronic pancreatitis and PEI.

Clinical Overview of Chronic Pancreatitis & PEI

The disorder known as gastroesophageal reflux disease (GERD) is brought on by the retrograde reflux of stomach contents into the oesophagus. Numerous people's lives are impacted by the clinical management of GERD, which also significantly uses up social and medical resources. Our esteemed expert, Dr. Manish Bhatnagar will discuss the diagnosis, management, and role of the interprofessional team in providing better care for patients with GERD in this session.

A Review of Gastroesophageal Reflux Disease

Gastrointestinal (GI) tuberculosis (TB) accounts for 1% to 3 % of all TB cases worldwide. It can occur in the context of active pulmonary disease or as a primary infection without pulmonary involvement.  This session aims to provide doctors with a comprehensive understanding of gastrointestinal tuberculosis, a significant health concern worldwide. Dr. Bhatnagar will delve into the epidemiology, pathogenesis, clinical manifestations, and diagnostic approaches related to this condition. He will share evidence-based strategies and practical tips to aid doctors in effectively diagnosing and treating patients with this condition.

GI Tuberculosis: An Overview

Discover a new world of medical research with our outstanding speakers at the upcoming Changing Practice : November Roundup, which is being hosted by the renowned expert Dr. Mahadev Desai. We'll be talking about some excellent studies in the field of rheumatology and recent articles from BMJ, a distinguished expert panel will be there to offer advice. Get a seat at this #MustAttendSession, broadcast live only on Medflix, to advance your medical expertise!

Changing Practice - November Round Up

Fatty liver disease, once considered a benign condition, has emerged as a significant health concern with far-reaching consequences. There is an intricate relationship between fatty liver disease, metabolic syndrome, insulin resistance, obesity, and other metabolic disorders. Let's Explore and Understand the risks and implementing appropriate monitoring and management strategies with Dr. Manish Bhatnagar in preventing disease progression and improving patient outcomes.

Fatty Liver: No more a Benign Disease

Proton pump inhibitors (PPIs) are a mainstay in the management of acid peptic disorders; they are highly effective at relieving symptoms and are generally well tolerated. However, there is growing concern about their increasing use owing to being linked to a number of adverse events (PPI-associated adverse events [PAAEs]). Therefore, de-prescribing of PPIs is considered an important strategy to lower pill burden. Join in LIVE with renowned senior gastroenterologist, Dr Manish Bhatnagar, to understand the latest recommendations in prescribing & de-prescribing proton pump inhibitors. 

PPI's: Too much of a good thing?

Probiotics have been widely studied in a variety of gastrointestinal diseases. Clinicians remain confused by the lack of precise instructions on when to use probiotics and which probiotic is best for treating certain gastrointestinal problems. There has been great interest in the role of probiotics and the treatment of childhood diarrhoea, antibiotic associated diarrhoea, Clostridium difficile infection, Irritable bowel syndrome and inflammatory disease. In this discussion with Dr. Manish Bhatnagar, we will first illustrate the concept of prebiotics & probiotics, covering the most recently well-established scientific findings regarding the direct and indirect mechanisms by which these dietary approaches can influence gut immunity.

Prebiotics, Probiotics & the Gut Microbiome

Jaundice, a clinical manifestation of elevated serum bilirubin, is a common clinical finding in clinical practice. Jaundice is most often caused by decompensation of preexisting chronic liver disease, alcoholic hepatitis, and gallstone disease. Careful history, physical examination, and routine laboratory tests lead to accurate diagnosis in most patients with jaundice. Renowned gastroenterologist Dr Manish Bhatnagar provides a comprehensive description of the day-to-day clinical picture of jaundice, which will undoubtedly streamline our approach to treating it in routine practise.

Approach to Jaundice: Day-to-day Hepatology

Join us live as we celebrate Medflix's two-year milestone with an incredible night filled with joy, laughter, exciting games, and amazing prizes for everyone! Don your party hats and join in on this wonderful celebration that is sure to be fun and festive.

Medflix Anniversary Special 

Upper GI bleeding includes hemorrhage originating from the esophagus to the ligament of Treitz, at the duodenojejunal flexure. It can be categorized based upon anatomic and pathophysiologic factors: ulcerative, vascular, traumatic, iatrogenic, tumors, portal hypertension & usually presents with hematemesis, “coffee-ground” emesis, and/or melena. Peptic ulcer disease: the most common cause, accounts for about half of major upper GI bleeds. Dr. Manish Bhatnagar, renowned Senior Consultant in Gastroenterology, is here to provide us all with a practical diagnostic algorithm to the case of suspected upper gastrointestinal bleeding(UGIB). The discussion is aimed to address the dilemmas in diagnosis of an upper GI Bleed, which in turn will guide us towards definitive investigations and interventions.

Diagnostic Dilemmas: Upper GI Bleeding

The defining features of IBS are the presence of recurrent abdominal pain in association with altered bowel habits & the spectrum, duration and severity of symptoms can range from inconvenient to incapacitating. IBS presents an interesting conundrum given its diagnostic ambiguity and overlap with other functional gastrointestinal disorders. The Rome criteria currently divide IBS into 4 subtypes based on the most prominent bowel habit: IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), IBS with mixed bowel habit (IBS-M; with alternating between constipation and diarrhea) and IBS unclassified (IBS-U). To simplify the diagnosis and treatment modalities of IBS, we have Dr. Manish Bhatnagar join us on Medflix for an in-depth guide on the approach to IBS. 

Gut Check: Approach to IBS Diagnosis and Treatment

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract and includes both Crohn's disease and ulcerative colitis. Given that the presentation of IBD is not specific, the differential diagnosis is broad and encompasses a wide spectrum of diseases, many of which can mimic and/or even coexist with IBD. Mycobacterium tuberculosis ('the great mimic') may coexist with IBD or mimic CD entirely. Accurate diagnosis of IBD and exclusion of these mimics are crucial for patient management. Renowned senior gastroenterologist Dr. Manish Bhatnagar helps us address these dilemmas in diagnosis with a few interesting cases and clinical scenarios! 

Diagnostic Dilemmas : IBD

Association of Physicians of India - APICON 2023 & Medflix jointly present India's largest LIVE medical quiz series! Prepare for the most thrilling quizzes of the year! 7 days, 7 specialties & unlimited learning. Our faculty Quizmaster for this editon is Dr. Manish Bhatnagar, a renowned Gastroenterologist with over 2 decades of experience. Join in, play along, and obtain insightful clinical knowledge while winning fun cash prizes and taking home your API certificate of attendance. Experience the joy of learning medicine, tune in on 10th Jan at 9PM!

APIQUIZ : Gastroenterology Edition

Consultant Gastroenterologist, Hepatologist & Therapeutic Endoscopist | Chairman - ICON Hospital, Ahmedabad

Dr. Manish Bhatnagar

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