A meta-analysis has uncovered a striking connection between hidradenitis suppurativa (HS) and psychiatric disorders (PD).

**Key Findings:**

- Patients with HS had twice the higher risk of depression (20.9% vs. 8.35%) and nearly double the risk of anxiety (19.3% vs. 8.14%) compared to the general population. 

- Bipolar disorder (1.04% vs. 0.06%, OR 3.68), schizophrenia (2.68% vs. 1.23%, OR 2.00), and completed suicide (0.67% vs. 0.44%, OR 1.56) were also more common in HS patients.

- Risk of depression rose with disease severity, affecting 35.3% of patients with Hurley Stage III HS.

- Psychiatric disorders were more prevalent in females with HS (28%) than in males (21%), and adults were twice as likely as children to experience depression (19.1% vs. 9.51%).

This study underscores the need for heightened awareness and proactive mental health support for HS patients to improve their overall quality of life.

Source: Oxford Academic | [Read Full Story](https://academic.oup.com/bjd/advance-article-abstract/doi/10.1093/bjd/ljaf151/8116457?redirectedFrom=fulltext&login=false)

Hidradenitis Suppurativa Patients Face Increased Risk of Depression, Anxiety, and More

A recent guideline from the American College of Chest Physicians (CHEST) advised against routine transfusion of platelets and fresh frozen plasma (FFP) in critically ill adults.

Transfusions are not recommended in stable non-bleeding patients with thrombocytopenia or coagulopathy and are advised only when platelet counts fall below 10 × 10⁹/L (without spontaneous bleeding), 30-50 × 10⁹/L (with spontaneous bleeding risk), or <50 × 10⁹/L (in actively bleeding patients). 

Routine prophylactic transfusion before bedside procedures is discouraged, except in rare cases like lumbar puncture.

Source: Chest Journal | [Read Full Story](https://journal.chestnet.org/article/S0012-3692(25)00279-X/fulltext)

New CHEST Guidelines Warns Against Fresh Frozen Plasma and Platelet Transfusions in Critically Ill Patients

Atopic conditions such as asthma, allergic rhinitis, and atopic dermatitis may predispose individuals to knee osteoarthritis (OA), according to a nationwide Korean cohort study. 

Analysis of over 880,000 adults aged ≥50 revealed a 36% higher risk of knee OA in those with atopic disease (HR 1.36), with risk escalating for those with multiple conditions—44% for two conditions and 51% in those with all three.

The association was strongest in those aged 50-59 (HR 1.40), males (HR 1.41), and non-obese individuals (HR 1.39) compared to obese individuals (HR 1.31).

The study underscores the role of chronic inflammation in OA development, suggesting the need for targeted interventions to prevent knee OA in atopic patients.

Source: Science Reports | [Read Full Story](https://www.nature.com/articles/s41598-025-92247-7)

Chronic Inflammation from Atopic Conditions May Drive Knee Osteoarthritis

Patients who underwent dialysis before kidney transplantation face a significantly higher risk of long-term ocular, new research shows.

Dry eye affected 21.8% of dialysis patients versus 12% of those transplanted pre-emptively, while diabetic retinopathy occurred in 25.3% vs 16.2%, respectively. Rates of cataracts, glaucoma and others ocular conditions remained similar in both groups.  

The findings pinpoint pre-transplant dialysis as a key contributor to post-transplant vision issues, underscoring the need for early ophthalmologic monitoring—especially in dialysis-dependent patients.

Source: Science Reports | [Read Full Story](https://www.nature.com/articles/s41598-025-99847-3)

Increased Rates of Ocular Complications in Dialysis-Dependent Kidney Transplant Recipients

A massive cohort study tracking over 8 million births highlights the elevated hospitalization risks in children exposed to syphilis during pregnancy, regardless of whether they had congenital syphilis.

**Key Findings:**

- Children with congenital syphilis faced a striking 11.53-fold higher risk of hospitalization in the first month of life, with risk remaining elevated until age 3.

- Congenital syphilis was linked to nearly 6 times higher risk of hospitalization.

- Exposure to maternal syphilis was associated with a 1.90-fold increased risk (HR 1.90).

- Exposed children had more frequent and longer hospital stays, with respiratory and digestive conditions being more common in the maternal syphilis and nonexposed groups.

These findings emphasize the long-term impact of syphilis exposure in utero and reinforce the urgent need to prevent maternal infections and closely monitor exposed infants.

Source: JAMA Network | [Read Full Story](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833330)

Children Exposed to Syphilis in Utero Face Elevated Hospitalization Risks, Study Reveals

Continuous positive airway pressure (CPAP) therapy significantly reduces the risk of major adverse cardiovascular and cerebrovascular events (MACE)—but only in a select subgroup of patients with high-risk obstructive sleep apnea (OSA). 

Among these patients, CPAP reduced MACE risk by 17% (HR: 0.83), with stronger effects seen in those without excessive daytime sleepiness or high blood pressure (interaction HRs: 0.59 and 0.54, respectively). 

This study highlights the need for precision in OSA treatment, suggesting cardiovascular protection from CPAP is not universal, but reserved for physiologically high-risk individuals.

Source: ATS Journals | [Read Full Story](https://www.atsjournals.org/doi/abs/10.1164/ajrccm.2025.211.Abstracts.A5286?af=R)

CPAP Lowers Cardiovascular Risk, but Only in High-Risk Obstructive Sleep Apnea Patients

Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) therapy significantly reduced the risks of major adverse cardiac and cerebrovascular events (MACCE), non-occlusive ischemic events (NACE), all-cause mortality, and revascularization without increasing bleeding risks. 

Patients on PCSK9i had a reduced risk of NACE (aHR: 0.674), MACCE (aHR: 0.674), and all-cause death (aHR: 0.501). The matched win ratio analysis strongly favored PCSK9i (0.634). 

This study fills a critical knowledge gap in understanding the combined use of PCSK9i and antiplatelet therapy for reducing ischemic events without compromising safety.

Source: International Journal of Cardiology  | [Read Full Story](https://www.internationaljournalofcardiology.com/article/S0167-5273(25)00395-X/abstract?rss=yes)

PCSK9 Inhibitors Reduce Ischemic Events Without Increasing Bleeding Risk in Post-PCI Patients

A population-based study of over 1.9 million participants reveals that clinically diagnosed cerebral amyloid angiopathy (CAA) carries a strikingly elevated risk of death and stroke. 

**Key Findings:**
- CAA was linked to nearly a fivefold higher risk of mortality (HR: 4.9). 
- Among patients without prior stroke, CAA was associated with a markedly increased risk of any stroke (HR: 8.0), ischemic stroke (HR: 4.6), intracerebral hemorrhage (HR: 26.9), and subarachnoid hemorrhage (HR: 21.6). 

These findings highlight the urgent need for vigilant stroke prevention strategies in patients with CAA.

Source: Wiley Online Library | [Read Full Story](https://onlinelibrary.wiley.com/doi/10.1002/ana.27253?af=R)

Clinically Diagnosed Cerebral Amyloid Angiopathy Carries High Mortality and Extreme Stroke Risk

Optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) delivers significantly better stent implantation outcomes than traditional angiography in patients with calcified coronary lesions. 

**Key Findings:**
- The study enrolled patients with stable moderate to severe calcifications, revealing a markedly larger final median minimal stent area in the OCT group compared to the angiography group (6.5 mm² vs 5.0 mm²). 
- OCT-guided PCI involved more frequent use of intravascular lithotripsy (46% vs 12%). 

This study supports OCT as a superior imaging strategy, potentially redefining standard care to enhance long-term results in a high-risk population.

Source: Jama Network | [Read Full Story](https://jamanetwork.com/journals/jamacardiology/fullarticle/2832995)

OCT Outperforms Angiography in PCI for Calcified Lesions

Patients who underwent thrombectomy were found to have a significantly increased risk of recurrent stroke beyond 90 days after hospital admission. 

These patients had a 2-year stroke and palliative care-free survival rate of just 36.6%, compared to 45.8% in those who did not undergo the procedure (adjusted HR 1.19). While overall mortality or need for palliative care was similar between groups (HR 0.89), the incidence of new stroke was notably higher in the thrombectomy cohort (HR 1.25). 

These findings spotlight the critical need for aggressive secondary prevention strategies and prolonged surveillance in post-thrombectomy stroke survivors.

Source: Frontiers | [Read Full Story](https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1543101/full)